None of the SNPs tested for an association met genome-wide significance (p<5.0×10−8) with any ECG trait. Although we did not detect associations at genome-wide significance, we were able to detect novel associations at p<10−6 (Table 2, Supplementary Fig. 1). Nine common variants were associated with increased heart rate, representing five independent disease loci. Three SNPs were in complete linkage disequilibrium with each other (r2= 1.0) in SERPINI1 on chromosome 3. Aside from SNPs associated with heart rate, nine associations at p<10−6 were observed for QT interval, QRS duration, and PR interval, separately (27 associations total). Collectively, these potentially novel associations represent 17 candidate genes throughout the genome associated with these traits. None of these associations have been reported by previously published GWAS for ECG traits in any population.
