According to LD estimation in the large FINRISK sample (N = 19857), rs56113850 and rs12461964 share an LD block with the known reduced activity allele CYP2A6*2, and esv2663194 shares a block with the known reduced activity allele CYP2A6*9, while rs113288603 is located outside these LD blocks (S5 Fig). Based on pairwise LD values both CYP2A6*2 and CYP2A6*9 exhibit strong LD with all four independent SNPs (S4 Table), and after conditioning on the top-SNP (rs56113850) neither were genome-wide significant (S5 Table).
