Age, sex, and BMI explained altogether 8.9%, 6.1%, and 0.53% of the variance in NMR in FinnTwin, YFS, and FINRISK2007 samples, respectively. The top-SNP rs56113850 alone explains 14–23% of the variance in NMR in the three cohorts (Table 2). Further, the percentage of variance explained by the three independent SNPs (rs56113850, rs113288603, and esv2663194) when jointly included in the model was 20.8% in FinnTwin, 31.4% in YFS, and 26.3% in FINRISK (increasing to 27.7% when rs12461964 was included).
