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Chunk #8 — Introduction

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A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism.
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The current analyses go beyond these recent papers by focusing on four clinically-based outcome categories observed an average of two decades later in a large group of men and women with AUDs at baseline. Similar detailed drinking-related follow-up data could not be generated for deceased subjects, and, consequently, those individuals are the focus of a separate paper. Based on prior work (Gonçalves et al., 2017; McCutcheon et al., 2017), the analyses were structured to evaluate five hypotheses. Hypothesis 1 predicted that, based on our prior studies and additional data (e.g., Helzer et al., 1985), follow-ups carried out several decades later will show that less than 20% of these subjects will report recent Low-Risk Drinking. Hypothesis 2, also based on or prior studies, stated that recent Low-Risk Drinking would be predicted by a pattern of baseline characteristics that included lower alcohol use parameters and higher sensitivity to the effects of alcohol (a high LR; the opposite of a low LR to alcohol), less drug use and problems, as well as lower indications of externalizing characteristics regarding conduct problems, Novelty Seeking, and