Low LR heritabilities are 40% to 60% and animal studies have confirmed alcohol stimulation in some genetic lines of alcohol referring rodents (e.g., Cunningham et al., 1992; Masur et al., 1986). Several studies confirm that lower and higher alcohol responses that may operate at different phases of the BAC curve or relate to the rapidity of rise of alcohol blood levels may be related to each other (e.g., King et al., 2016; Ray et al., 2016; Schuckit et al., 2002) and thus both types of measures have been included in this review of gene variants that potentially relate to alcohol sensitivity.
