Chunk #52 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Genotyping: Allele frequencies were assessed in 14 DNA pools, each containing equal amounts of DNA from 20 individuals of the same phenotype group, using four sets of four arrays, two from “100k” and two from “500k” Affymetrix SNP arrays, using approaches that were extensively validated as noted above.