C. Sample 3) European-American alcohol dependent and control [33] Unrelated individuals sampled from pedigrees collected by the Collaborative Study on the Genetics of Alcoholism provide an interesting sample for several reasons. Dependence on alcohol and other substances has been carefully characterized in these individuals using validated instruments. Unrelated control individuals free from substance abuse or dependence diagnoses, largely individuals who marry into these pedigrees, are available. We thus identified 120 unrelated alcohol dependent individuals and 160 unrelated unaffected controls with self-reported European-American ethnicities.
