Chunk #50 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Data for each SNP provides a score that provides a continuous measure of the percentage of its two alleles in the DNAs from the hetero- and homozygous individuals represented in each pool. For SNPs that displayed nominally-significant differences between addicted and control individuals in 600k studies, there were r ≥ 0.9 correlation between the magnitude of the differences between pooled vs individual genotyping approaches. Variance from array-to-array (assessing the same DNA pool) and variance from pool-to-pool were both modest, ca 3%, supported good validity of this pooling data. Results from 1M SNP assays provide even more modest pool to pool and array to array variances (Liu et al, in preparation).