AUDIT-C and AUDIT-P PRS accounted for increasing proportions of phenotypic variance in AUDIT-C and AUDIT-P scores as the sample aged, from ~0.50% at age 16 to 1.12% at age 23 (see Supplementary Tables 8–9 for complete results). Here we focus on results for age 23 for comparability to other samples, which consisted predominantly of adults. No association survived the correction for multiple tests. The strongest associations observed were for AUDIT-C and AUDIT-P PRS, which were both associated with higher AUDIT-C scores in ALSPAC at age 23, each explaining 0.60% of the variance (p = 1.06e-3 and 5.9e-4, respectively), and between AUDIT-P PRS and MaxDrinks (R2= 3.30%, p = 1.59e-3); a 1-SD increase in AUDIT-P PRS corresponds to a predicted increase of 0.54 drinks.
