The BA6 region of the precentral gyrus implicated in the current study is part of the dorsal premotor cortex, suggesting that altered connectivity may contribute to differences in motor behaviors. In this sample, we previously reported group differences in visuospatial working memory.6 FHP and FHN groups also showed differences on Trails B (participant switches between number and letter; A-1; B-2; C-3, etc.) but not on Trails A (participant connects numbers rapidly in sequential order). Trails A may index basic visuomotor task performance, whereas Trails B may tap higher-order executive functions. Interestingly, Trails A performance was the only measure that correlated with connectivity within this region, possibly indicating that altered connectivity may contribute to deficits on some tasks that rely primarily on motor performance. It is important to note that the portions of the precentral gyrus, especially dorsal components, are known to play an important role in cognitive, as opposed to purely motor, processes. For instance, Hanakawa et al. demonstrated that this region is involved in mental operations that did not require overt movement.37 Consequently, it is possible that some cognitive
