In the current analysis, we explore the overlap between the externalizing spectrum and suicide-related outcomes in the Million Veteran Program (MVP) cohort. First, we validated a latent genomic factor for externalizing in MVP (MVP-EXT), comparing results to a previously published genome wide association study (GWAS)16. Next, compared the overlap of MVP-EXT and suicide-related outcomes using genetic correlations and polygenic scores in external cohorts to further explore these associations. Third, we used GWAS results to explore cell type enrichment in postmortem brain tissue of individuals who died by suicide compared to non-suicide deaths. Lastly, we performed a prospective analysis that evaluated the relationship between externalizing from electronic health records (EHR) and suicide mortality within the MVP cohort.
