Chunk #77 — Potential for Translational Applications of Electrophysiological Measures of Brain Function — Electrophysiological Measures As Endophenotypes for Alcoholism
and alcohol dependence during adolescence and young adulthood (Chorlian et al. 2013). Hill and colleagues (2013) used group-based trajectory modeling of auditory P3 data collected longitudinally from offspring in families with and without familial risk for AUD and found that specific trajectories of P3 were associated with familial risk and CHRM2 variation, with high familial risk in male offspring. These findings underscore the utility of P3-related measures as effective endophenotypes in genetic studies of psychiatric disorders.
