LD bins tagged by rs9298626 and rs892413 each show association with DSM-5 cocaine use disorder in joint SNP analysis. Analyses conditioning on rs9298626 reveal that rs892413 is independently associated with DSM-5 cocaine use disorder. rs892413 is also associated with DSM-5 cocaine use disorder independent of the previously identified genome-wide significant association in the region with nicotine dependence (represented by rs1451240), providing support for a direct effect of this SNP on higher DSM-5 cocaine use disorder risk, as opposed to acting through nicotine dependence risk (Tables 3 and 5).
