For bipolar disorder, three individual studies (with 1,000-2,000 cases each) failed to detect significant association, but the three datasets combined produced a p-value of 9.1 × 10−9 in ANK3 (ankyrin-G, whose product links membrane proteins such as voltage-dependent sodium channels to the axonal cytoskeleton). (41, 59, 60) A significant association (in DGKH) reported in a smaller study using pooled genotyping was not seen in the larger analysis.(71)
