Throughout the past 18 years, DrugBank's content, accessibility and layout have continuously evolved, reflecting advances in hardware and internet technology, requests from its diverse user community and specific needs identified by the DrugBank curation and programming teams. DrugBank 1.0, released in 2006, provided modest amounts of data on selected FDA-approved drugs and their drug–targets in a convenient web-based format (6). Over the following two decades, DrugBank has gone through multiple updates, that have included important additions such as pharmacogenomic data, drug metabolism data and comprehensive ADMET (absorption, distribution, metabolism, excretion and toxicity) information. DrugBank 5.0, the last update which appeared in 2018, added more investigational drug data, new drug–drug interaction data, new types of pharmaco-omic data and a significant amount of drug spectral (MS and NMR) information (7).
