et al., 2013). Rs1789891 was associated with alcohol dependence in a study of British and Irish (p = 7.2×10−5; OR =0.71), and the association remained significant when conditioned on rs1229984 (ADH1B*2; p = 1.7×10−4) (Way et al., 2015). In the PGC-SUD trans-ancestral meta-analysis, rs1789912 was associated with alcohol dependence (p = 1.47×10−9) (Walters et al., 2018); it is in complete LD with rs698/rs1693482 (r2 = 1). In analyses of Europeans, conditional on ADH1B*2, the 2 SNPs that define ADH1C*1 and 2 others (rs1789912, rs1154445; pconditional = 7.7×10−4, 1.7×10−4) that were in complete LD (r2 = 1) with them retained some evidence of association (Walters et al., 2018).
