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Chunk #19 — RESULTS — Effects of SDPS on alcohol taking and alcohol seeking — Progressive ratio

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Stress vulnerability promotes an alcohol-prone phenotype in a preclinical model of sustained depression.
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was detected. Accordingly, a significant group effect in break points over the five PR sessions was observed, repeated measures ANOVA F GROUP(2, 32) = 3.44, P = 0.044 (Figure 3C). Post hoc comparisons revealed that this effect was driven by a strong increase in break points displayed by the SDPS‐prone animals (P = 0.016 vs control), an effect that was absent in SDPS‐resilient rats (P = 0.121 vs control). No difference in break points between the two SDPS groups was observed (P = 0.388). Taken together, PR data confirmed that SDPS enhances motivation for alcohol seeking20 and suggested that, to a large extent, SDPS‐resilience prevents these motivational deficits.