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Chunk #20 — RESULTS — Effects of SDPS on alcohol taking and alcohol seeking — Retraining on FR1

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Stress vulnerability promotes an alcohol-prone phenotype in a preclinical model of sustained depression.
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Following PR, all animals were subjected to FR1 retraining (13 1‐hour sessions; reFR1) in order to normalize preexisting group differences at the start of extinction (Figure 4A). Repeated measures ANOVA revealed a significant training effect, F reFR1(4.54, 145.43) = 9.18, P < 0.001, and no group × training interaction, F reFR1 × GROUP(9.09, 145.43) = 1.14, P = 0.335, as all animals gradually reduced responding for an alcohol reward (Figure S3). A significant group effect, F GROUP(2, 32) = 5.83, P = 0.007, pointed toward differential group performance over time. Post hoc analysis further confirmed that, similar to acquisition in FR1, SDPS‐prone rats showed enhanced responses vs controls (P = 0.002). This effect was not seen in SDPS‐resilient animals (P = 0.124 vs controls). No differences between SDPS‐prone and SDPS‐resilient groups were detected (P = 0.105). Notably, an initial carry‐over effect in responding after PR was observed in the SDPS‐prone group, which displayed higher number of active responses when compared with both control (P = 0.001) and SDPS‐resilient (P = 0.018) groups at the first reFR1 session. Together, retraining in