Performing a similar admixture analysis but this time considering each individual Native American population as ancestral, revealed several instances of increased similarity between the Native component in the Mestizo and Native populations located in relative geographic proximity (Figure 1, Figure 6 and Table S5). Most notably, Quetalmahue (in Southern Chile) shows a strong genetic similarity to the Huilliche, a Native population from the vicinity. Also, the population of Paposo in Northern Chile is markedly more similar to the neighboring Aymara than to any other Native American population. The three populations from North West Argentina (Salta, Tucuman and Catamarca) show greatest genetic similarity to the Quechua (sampled in Southern Peru) and the Aymara (sampled in Northern Chile). The population of Pasto in Southern Colombia is most similar to the Inga, a Quechua-speaking population also from Southern Colombia. Peque in North-West Colombia shows greatest similarity to the Wayuu (sampled in Northern Colombia and genetically closest to Chibchan-speakers, although not classified as Chibchan[23]) and the Cabecar (from Costa Rica, in lower Central America). The Cabecar are also the Native population most similar to
