effects represents a lower response per drink; the equivalent of a low LR on alcohol challenges [8, 9, 34–36]. The SRE has a Cronbach alpha >.90; retest reliabilities >.80; SRE-based LR scores correlate well with alcohol challenges evaluating alcohol-related changes after consuming alcohol; relationships of the LR scores among first-degree relatives are higher than among unrelated individuals; and a low LR predicts heavier drinking and alcohol problems five years later [8, 9, 34, 35].