To increase the precision of our estimates of the SNPs’ effects on general risk tolerance, we leveraged the high degree of genetic overlap across our phenotypes by conducting Multi-Trait Analysis of GWAS (MTAG)16. We used as inputs the summary statistics of our GWAS of general risk tolerance, of our first five supplementary GWAS (i.e., not including the first PC of the four risky behaviors), and of a previously published GWAS on lifetime cannabis use25 (Supplementary Note). MTAG increased the number of general-risk-tolerance lead SNPs from 124 to 312 (Supplementary Fig. 7 and Supplementary Table 10).
