Depression-PRS (DEP-PRS) were calculated for 4,973 individuals of European ancestry from the Philadelphia Neurodevelopmental Cohort (PNC)65,66 using the primary depression GWAS meta-analysis (and narrowly defined depression GWAS meta-analysis) of the current study as training. Genotypes from the first PNC release (dbGaP phs000607.v1.p1) and neurocognitive phenotypes from the third release (dbGaP phs000607.v3.p2) were utilized. Individuals whose genotypically inferred and phenotypically reported sex did not match, those who did not meet the identity by descent (IBD) filter (π^>0.185), those who did not meet the individual-level missingness filter of 0.05, and those with heterozygosity rates +/− three standard deviations from the mean were removed. SNPs that failed to meet the Hardy-Weinberg proportions (HWP), minor allele frequency (MAF), and SNP-level missingness filters of 0.00001, 0.01, and 0.05, respectively, were also removed. Genotype imputation was performed using the reference panel HRC r1.1 2016 on the Michigan Imputation Server (https://imputationserver.sph.umich.edu/index.html#!). selecting the “Mixed population” option. Imputed SNPs with an imputation R2<0.03 and those who failed to meet the missingness, MAF, and HWP thresholds stated above were removed. The first two Multi-Dimensional Scaling (MDS) dimensions were plotted
