We conducted a meta-analysis of the PGC MDD and the CHARGE depressive symptoms GWAMA using a weighted, P-value based meta-analysis. The results are summarized in Figure 1 and Figures S1–S3. The combined meta-analysis was conducted for 918,921 SNPs. Two loci were genome-wide significant: a SNP in an intron of FHIT (rs9825823, chr3: 61,082,153, P =8.2×10−9) and a SNP in an intron of PLEK2 (rs9323497, chr14: 67,873,128, P=3.3×10−8) (Table 1). All SNPs with a P value of association <5×10−5 are presented in Table S2. Using different weights or Stouffer’s unweighted method had only slight effects on the results (data not shown). Figures S4 and S5 shows forest plots for two SNPs shown in Table 1.
