Table 2 presents the replication analyses and the meta-analysis of discovery and replication results. One of the genome-wide significant variants within the FHIT gene (rs9825823) was associated with depression continuum in the replication cohorts (z-score=2.4, P=0.02). The result of the final metaanalysis of discovery and replication samples also indicated a positive replication as indexed by a lower p-value (z-score=6.1, P=1.0×10−9). This SNP had a positive association with depressive symptoms in the CHARGE study (P=5.5 × 10−4) and a similar pattern was observed in the PGC study (P=4.1 × 10−6). The SNP in an intron of PLEK2 (rs9323497) was not related to depression continuum significantly (z-score=0.2, P=0.9).
