Data are derived from the original Science publications of 3 GWA investigations and their replication efforts (advance online publications in Science on April 26, 2007 [10], [11], [13]). These investigations were conducted by the Finland-United States Investigation on NIDDM Genetics (FUSION) team, the Diabetes Genetics Initiative, and the Wellcome Trust Case-Control Consortium. Extensive details of the design and populations of these investigations have been presented in the original publications [10], [11], [13]. In brief, all three publications used a discovery dataset where GWA evaluation was performed on Illumina or Affymetrix chips and promising genetic variants were further tested for replication in large replication datasets. The number of polymorphisms tested in the discovery phase of each investigation were 317503, 500568, and 499032, respectively and the number of polymorphisms that were considered to have data suitable for analyses were 315635, 386731, and 393453, respectively. The FUSION investigation used 1161 cases and 1174 controls in the discovery phase and 1215 cases and 1258 controls in the replication phase. The Diabetes Genetics Initiative investigation used 1464 cases and 1467 controls in the discovery phase
