Furthermore, the recurrence of a single seizure might lower the threshold for new seizures to occur in TLE patients [6], [43]. From this perspective, it might be hypothesized that not only structural changes due to the lesion alter the functional network configuration, but the seizures do as well. We speculate that lesion and seizures affect the local neural networks in such a way that they become more prone to seizures, which might play an important role in the recurrence of epilepsy after a latency period in TLE patients.
