An unexplained phenomena in TLE is its course, which is often characterized by a seizure-free latency period after initial onset, eventually ended by recurrence of seizures. Because of this course, it is suggested that TLE should be seen as a progressive disease. Bernasconi and others found progressive volume loss of the hippocampus, the amygdala, and the entorhinal cortex in TLE patients, which is the structural manifestation of progression [4]. The possible emergence of an epileptogenic network during the silent period of TLE has been described [40]. There seems to be a randomness threshold, beyond which a network is prone to seizure-like behaviour. Neural networks of TLE patients may become more random during the latency period, allowing this threshold to be crossed and thus resulting in seizures recurrence [41], [42]. Our findings support the hypothesis of such a transition, changing the network configuration over time to a more random state which is more prone to seizures.
