Follow-up linkage analyses of the 12 alcohol dependence symptoms assessed by the SSAGA were then conducted for the reported linkage peaks. For the chromosome 1 peak at 114 cM, a broad range of symptoms assessing 4 of the 7 DSM-IV symptom clusters yielded evidence of linkage within the support interval. Both the chromosome 2 peak at 32 cM and the chromosome 22 peak showed evidence of linkage with symptoms that fell into 3 of the 7 symptom clusters. Finally, the chromosome 9 region yielded evidence for linkage with a narrower range of symptoms with only 2 of the 7 DSM-IV symptom clusters represented. The symptom-specific LOD scores are shown in Table 3.
