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Chunk #23 — 3. Results — Alcohol Dependence without Temporal Clustering of Symptoms

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Linkage scan of alcohol dependence in the UCSF Family Alcoholism Study.
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dependence diagnosis when the temporal clustering criterion was used (LOD = 1.11). The fifth peak was located on chromosome 9 at 18 cM (LOD = 1.70) with a support interval that extended from 6 – 27 cM, and the sixth peak was located on chromosome 22 at approximately 36 cM (LOD = 1.78) with a support interval that extended from 29 – 47 cM. Notably, there was no evidence of locus heterogeneity as each pedigree had an estimated alpha of >0.99 for each peak as estimated by HLOD (Goring, 2002).