Fine-mapping of the 27 loci identified credible variants, but only four variants had posterior probabilities greater than 0.5 in all three fine-mapping methods, and none were linked to specific genes based on our functional annotation analyses. Linking the credible variants to genes by integration with functional genomics data identified 76 prioritized risk genes, which were enriched among genes upregulated during early embryonic development and involved in cognitive abilities identified by GWAS of cognitive phenotypes. Among the 76 genes were PPP1R16A and B4GALT2 (mapped by psychENCODE eQTLs; Supplementary Fig. 12a,b), which were also the top-ranking genes in our TWAS of DLPFC expression, both showing a predicted decreased expression in cases compared to controls. These genes have not previously been linked to psychiatric disorders, but both have been linked to educational attainment51. The set of risk genes also included PTPRF, SORCS3 and DCC, which encode integral components of the postsynaptic density membrane. Involvement of postsynaptic components in the pathology of ADHD has been reported previously53 and also for SCZ54. We also highlight FOXP1 and FOXP2. The association signals were located within the
