DCC, which encode integral components of the postsynaptic density membrane. Involvement of postsynaptic components in the pathology of ADHD has been reported previously53 and also for SCZ54. We also highlight FOXP1 and FOXP2. The association signals were located within the transcribed regions of both genes and had credible variants being eQTLs (FOXP2, Supplementary Fig. 12c) or located in chromatin interacting regions (FOXP1, Supplementary Fig. 12d) in brain tissue. FOXP2 was identified in the ADHD2019 study14 and is also a risk gene for cannabis use disorder55, while FOXP1 is a new ADHD locus. Both FOXP1 and FOXP2 encode transcription factors that can heterodimerize to regulate transcription in brain tissues56,57 and have been implicated in speech disorders and intellectual disability58 by highly penetrant rare variants.
