The down-regulated treatment-responsive modules in the amygdala (salmon, white and darkolivegreen) were enriched for neuronal and glutamatergic genes (Table S11). The salmon module was also enriched for astrocytic and microglial genes. The down-regulated modules in the amygdala contained a large PPI network that included 76 genes in the glutamate receptor signaling pathway. Genes involved in cell surface receptor activity, including ion channel activity and tyrosine kinase signaling activity, were also prominent here.
