Webgestalt identified G-protein coupled receptor signaling pathways and neuro-active ligand receptor interaction pathways that were enriched in the up-regulated modules. Genes involved in neuropeptide signaling, neuropeptide receptor binding and neuropeptide hormone activity were also prominent. Study of the protein-protein interactions (PPI) identified several networks in the up-regulated modules, including adenylate cyclase activity and regulation of transcription processes. Genes critical for synaptic transmission dominated the up-regulated modules, including genes coding for ion channels such as voltage-gated potassium, calcium and sodium channels and GABA and glycine receptors.
