genes known to affect alcohol consumption (based on studies of mutant mice), and found that two of these modules contained more alcohol consumption-related genes than expected by chance (hypergeometric p < 0.01). Over half of the co-expressed alcohol consumption-related genes were also regulated by feno and tesa; for example, Pdyn (up-regulated 23% by feno and 24% by tesa), Penk1 (up-regulated 34% by feno and 49% by tesa) and Ppp1r1b (up-regulated 34% by feno and 67% by tesa) modulate alcohol consumption and are changed (in a coordinated manner) by feno and tesa.
