HaploReg (59) corroborated the regulatory potential of the putative cis-eQTL SNPs, showing that almost all of them are predicted to alter one or more of the regulatory motifs indicative of transcription factor binding sites (60, 61) (Table S6). Moreover, rs3778150 resides in a highly conserved region, and two of the SNPs (rs562859 and rs13203628) are located in DNase hypersensitivity and enhancer sites (Table S6).
