Analysis of the irritable temperament also produced two SNPs of GW significance (p<5×10−8) as shown in Figure 1. These SNPs lie within the neighboring INTS7 and DTL genes on chromosome 1, with several nearby SNPs providing additional support for the association to this region as and detailed in Figure 2c. INTS7 encodes a subunit of the Integrator complex that mediates 3′ end processing of small nuclear RNAs U1 and U2 (37). DTL encodes a denticleless homolog that may be necessary for the regulation of DNA replication. Again, these SNPs were not significant in the case-control analysis of BD in the Wave 5 subjects (see Table 3) or in the analyses of the other four temperaments. Again, several other genes of possible interest were identified, although the SNPs did not meet GW significance.
