Although the analyses of the dysthymic, cyclothymic, and anxious temperaments did not produce GW significant results, several genes of potential interest were identified as shown in Figure 1. Interestingly, the hyperthymic, dysthymic, and cyclothymic temperaments revealed associations to the same gene, LRRC4C, but to different regions within and around the gene as detailed in Figure 3. LRRC4C (formerly NGL1) encodes for a leucine rich repeat protein that functions as a specific binding partner for Netrin-G1 (NTNG1), which is a member of the netrin family of axon guidance molecules (38). No other genes were present in this region.
