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Chunk #4 — Results — Stage 1 Discovery Results

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Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
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After confirming a heritable component to directly imaged CT adipose tissue traits, we proceeded with GWAS. To assess for occult population stratification, we examined q-q plots for all traits (SAT, VAT, VAT-adjusted-for-BMI, and VAT/SAT ratio in the overall sample and in women and men separately), which can be found in Figure S1. All lambda values were <1.08, with little evidence to suggest unaccounted for population stratification. Manhattan plots for these traits can be found in Figure S2, with p-values<5.0*10E08 for the VAT/SAT ratio overall and VAT in women.