Our most significant finding was for rs11118316 at LYPLAL1 for the VAT/SAT ratio (Table S2). This SNP is in low to moderate LD with rs4846567 (r2 = 0.285, D′ 0.935), which was previously identified in the GIANT consortium in association with WHR-adjusted-for-BMI [32]. It is notable that in the GIANT consortium, rs4846567 was only associated with WHR in women (p = 4.9*10E-33) but not men (p = 0.36), whereas rs11118316 was associated with both women (p = 4.5*10E-6) and men (p = 8.3*10E-5) in the present analysis. We further note that for rs4846567, the p-value is 4.4*10E-04 in women but p = 0.05 in men. Thus, it is possible that we have identified a slightly different locus with varying sex differences. Our next genome-wide significant finding was for rs1659258 at chromosome 2 for VAT in women (p = 1.58*10E-08; Table S2 and Figure 1). Imputation scores for this SNP ranged from 0.98 to 1.0. This region has not previously been identified in association with adiposity phenotypes. Table 2 shows the results for rs1659258 across the abdominal adiposity traits in our
