This genetic association study was approved by the institutional review boards of all participating sites (Indiana University School of Medicine, SUNY Downstate Health Science University, Washington University School of Medicine, University of Connecticut School of Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, and University of California San Diego Medical School). All participants provided written consent. The study followed the Strengthening the Reporting of Genetic Association Studies (STREGA) reporting guideline.