Because of the large number of comparisons required to evaluate parental and risk group effects (Table 3 and Table 4), an adjustment for false discovery rate (FDR) was performed for these comparisons. This approach, originally proposed by Benjamini and Hochberg (1995), treats the p-values as ordered statistics (using ranks) and computes corresponding q-values which are then directly compared to the FDR chosen. The most conservative option was chosen.
