The family sample consisted of 548 probands and first-degree relatives with Tourette syndrome from 207 independent families(10). 175 probands came from the original Tourette GWAS1 sample; these cases were removed from the GWAS1 analysis along with ancestry-matched controls and re-analyzed with the family-based sample. 32 Tourette probands and 341 additional Tourette-affected family members (total N=373) were genotyped along with the GWAS2 case-control sample. 597 ancestry-matched controls were selected from a pool of previously genotyped controls (Supplemental Methods).
