attention and emotion and includes portions of the lateral prefrontal cortex and posterior parietal cortex. The FPN is implicated in cognitive control [12], and inhibits the DMN when it is irrelevant to task performance [13]. In the context of depression, evidence suggests that abnormal within-DMN rsFC may underlie the tendency for depressed individuals to engage in negative self-referential thought [14], whereas abnormalities in within-FPN rsFC may underpin depression-related cognitive deficits [15]. Furthermore, a failure of the FPN to effectively inhibit DMN activity may result in problems shifting attention away from internal thoughts to the external world and is one mechanism that may drive rumination [4, 16].
