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Chunk #19 — Results — Differences in the degree of methylation at each of the CpG sites between ethnicities in controls

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Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts.
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Comparisons between each pair of ethnicities were performed with the methylation levels in the controls at each CpG site (Table 4). There was an experiment-wise significant difference in the level of methylation between the African-American and Hispanic controls for the −25 (P = 0.0086), −10 (P = 0.0210), and the +12 CpG sites (P = 0.0447). Between the Hispanic controls and our previously reported Caucasian controls, an experiment-wise significant difference was found for the −25 CpG site (P = 0.0128). No experiment-wise significant difference was found between the African-American and the Caucasian controls.