No experiment-wise significant correlation was found in the level of methylation of all 16 CpG sites combined with age in either the African-American cases or controls or the Hispanic cases or controls. In the African-American controls (age range of 19–70 years, median 32, mean 33), the only CpG site with a point-wise significant correlation of methylation with age was at the −10 site (r2 = 0.2310, 95% CI 0.0009–0.4378, P = 0.049). In the African-American cases (age range of 20–65 years, median 46, mean 45), no CpG site was found to have a point-wise significant correlation of DNA methylation level with age. In the Hispanic controls (age range of 18–54 years, median 28, mean 31), there was a significant point-wise correlation of DNA methylation with age at the −60 CpG site (r2 = 0.31, 95% CI 0.03–0.54, P = 0.030). In the Hispanic cases (age range of 18–60 years, median 34, mean 35), there was a significant point-wise correlation of DNA methylation with age at the −18 CpG site (r2 = 0.19, 95% CI 0.00–0.36, P = 0.047). None of
