We first compared three AUDIT-C metrics (closest, highest, trajectory) to each other. Second, we compared the three AUDIT-C metrics to see which demonstrated the strongest association with a direct alcohol biomarker, phosphatidylethanol (PEth). Lastly, we compared the associations of the three AUDIT-C metrics with rs2066702, the Arg369Cys missense polymorphism of the ADH1B gene, which encodes an alcohol dehydrogenase isozyme that is common in African Americans (AA).
