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Chunk #20 — DISCUSSION

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Increased EEG coherence in long-distance and short-distance connectivity in children with autism spectrum disorders.
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The EEG coherence signals in resting state contain complex physiological information, which reflects the integration and processing of information by the brain in resting state and reflects the synchronization of the global brain neuron activity (Lord & Opacka‐Juffry, 2016). In the theory of nerve pruning, as the age of normal children grows, the myelin sheath of neurons matures and is further pruned and modified (Chugani, Phelps, & Mazziotta, 1987; Huttenlocher, De Courten, Garey, & Hendrik, 1982). The functional connections between the local or adjacent brain regions decreased, while the functional connections between remote brain regions increased (Fair et al., 2007). We found that children with ASD had excessive short‐distance connections in the left and right temporal–parietal regions, the right central–parietal regions, and the occipital regions. We speculate that enhanced short‐distance connections in children with ASD may due to over‐groomed nerves synaptic pruning. Additionally, synaptic abnormal theory hypothesizes that the enhanced functional integration in local brain regions may be contributed to the aberrant balance of excitation and inhibition in local neural circuits (Testa‐Silva et al., 2012; Tuchman & Cuccaro, 2011; Yizhar