synaptic pruning. Additionally, synaptic abnormal theory hypothesizes that the enhanced functional integration in local brain regions may be contributed to the aberrant balance of excitation and inhibition in local neural circuits (Testa‐Silva et al., 2012; Tuchman & Cuccaro, 2011; Yizhar et al., 2011), which is caused by either increased synaptic excitation or decreased synaptic inhibition (Yizhar et al., 2011). This aberrant balance has also been supported by blood biochemical studies in children with ASD (Cellot & Cherubini, 2014). Besides, we found that the coherence of children with ASD in the prefrontal region was significantly increased. Carper points out that the increased frontal lobe volume was obvious in the early brain development of autistic children (Carper, Moses, Tigue, & Courchesne, 2002). This transitional growth may lead to excessive connections in the frontal lobe (Coben & Myers, 2008; Rinaldi, Perrodin, & Markram, 2008), interfering with normal growth and development trajectories in ASD.
