Consistent with prior observations in a smaller subset of the study cohorts [16], substance use counts for each of the three substance use syndromes, AD, ND and CD, are significantly correlated with each other (Pearson Correlation; Table II). Additionally, for both sexes, ASPD symptom count is significantly correlated with each of the three substance use syndromes. However, MDD symptom counts were significantly correlated with SUD symptom counts in males, but not females.