Clinical and biomaterial from 516 subjects were used in this study. The demographic data and symptom counts for the subjects in the study are given in Table I. The study subjects are 55% female and 94% white. Consistent with Dr. Cadoret’s intentional loading of the study cohorts with adoptees with a biological family history of substance use and/or ASPD, high rates of substance use, MDD and ASPD are observed in the study subjects.
